Volume 7 Articles
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Volume 7 Articles
Multiple-Scale Computational Studies of Redox-Controlled Supramolecular Co-Assembly Nanoplat form: Toward Immunochemotherapy-Driven Antitumor Augment
Programmed cell death protein 1 (PD1)/programmed death ligand 1 (PD-L1) blockades provide an effective and safe therapeutic option in the field of refractory cancer therapy. However, not more than 30% response rate of most cancers seriously impedes their therapeutic efficacy. Previous investigations..........
View PDF View FulltextCytokine Storm Syndrome in COVID-19 Patients: Characteristics and Diagnosis
Cytokine storm syndrome (CSS) is a critical condition induced by a cascade of cytokine activation, characterized by overwhelming systemic inflammation, hyperferritinaemia, haemodynamic instability and multiple organ failure..........
View PDF View FulltextImpact of Anesthetics on the ST Segment Among Patients with Brugada Syndrome: Case Series
Brugada syndrome is a canalopathy causing rhythmic sudden death. The use of many drugs such as anesthetics but also many analgesics are contraindicated or not recommended in this pathology. The literature shows a low-level evidence while clinical experience may bring additional knowledge..........
View PDF View FulltextCase of Anthrax Abdominal Form in Kazakhstan
Anthrax is a dangerous zoonotic infection that is transmitted from farm animals to humans, when cutting, butchering infected animals, contact with meat and other animal products. Infection occurs by contact, alimentary, aerogenic pathways, while developing corresponding clinical forms - skin /ulcerative, abdominal / intestinal, pulmonary /pneumonic.........
View PDF View FulltextWen Dan Tang: A Potential Jing Fang Decoction for Headache Disorders
Chinese herbal medicine is considered relatively safe, inexpensive, and easily accessible. Furthermore, it is becoming increasingly popular in the western countries..........
View PDF View FulltextDeprescribing of Benzodiazepines in the Elderly Using A 3Es Model: A Patient Centered Approach
Benzodiazepines use in the elderly are associated with morbidity including increased falls, fractures, and mortality. The common reason for re-prescribing benzodiazepine by physicians is dependency. Our project........
View PDF View FulltextHepatic Artery Aneurysm Masquerading as Abdominal Pain in a Child: A Rare Case Report
Hepatic artery aneurysm is a rare clinical entity amongst children accounting for 20 % of all the splanchnic artery aneurysms, and if neglected could lead to catastrophic events..........
View PDF View FulltextAssociation between Body Mass Index and Severity According of Classification of Thyroid Cancer
Obesity is associated with aggressive pathological features and poor clinical out comes in breast and prostate cancers. However, the associations between excess weight and prognostic.........
View PDF View FulltextCardiac Transplantation in Patients with Muscular Dystrophy: A Case Report and Review of Literature
We report a case of slowly progressive Becker’s musculardy strophyina 52-year-oldman who required cardiactrans plantation for intractable congestive heart failure. A referral was madeconcerning prognosis of his.........
View PDF View FulltextA Case of Methotrexate-Associated Lymphoproliferative Disorder After Resection of an Accidentally Detected Enlarged Thyroid Tumor
We herein present a case of methotrexateasso-ciated lymphoproliferative disorder (MTX-LPD) with a diagnosisof an 8-mm thyroid tumor of class III cytology that grew three times larger during 2 years 8 months before resection..........
View PDF View FulltextRefractory Vasospasm andArterial Ischemic Stroke in Meningoencephalitis: Novel Intrathecal Nitroprusside Treatment
Acutestroke in bacterial mening it is in children contributes to high morbidity and mortality. The in cidence of strokeinped iatricmening it is isvaried, with reports between 8-42%, and as sociated mortality as high as 25%. The majority of these are arterial ischemic strokes(80-93%). Cerebralarterial vasospasm has been proposed. We present the first case of intrathecal nitroprusside used to treat refractoryvasospasminachildwithbacterialmeningoencephalitis complicated by acute ischemic stroke. .........
View PDF View FulltextHigh LOXL1-AS1 Lncrna Expression is a Prognostic Biomarker For Poor Prognosis in Cholangiocarcinoma
Cholangiocarcinoma (CHOL) is the most common malignant tumor of hepatobiliary system. The present study investigated the clinical significance and biological functions of LOXL1-AS1 in CHOL. The poor survival in CHOL has a probable prognostic molecular marker known as the LOXL1-AS1, and LOXL1-AS1 may be an important regulator of immune cell infiltration.........
View PDF View FulltextPublications Trends in Major Anesthesiology Journals: A 20-Year Analysis of Five Top-Ranked Journals in The Field
With the intention to quantify the importance of a medical journal, the impact factor (IF) was introduced. It has become a de facto fictive rating instrument of the importance of medical journals. Also, it is often used to asses the value of the individual publications within the specific journal. The aim of thepresent study was to analyze publication trends over 20 years in five high-ranked anesthesiology journals.........
View PDF View FulltextCardiopulmonary By pass Graftina PostCOVI-19 Thalassemic Patient
Thalassemia is of the most frequent haemoglobinopathy that includes a heterogeneous group of inherited autosomal recessive pathologies caused by defective synthesis of globin subunit that comprise haemoglobin production.........
View PDF View FulltextPrevalence and Predictors of Self-Medication in the Younger Elderly of Ahvaz based on Protection Motivation Theory
The use of medicines is one of the main parts of the treatment of diseases. However, self-medication can be fol- lowed several complications. The aim of this study was determine the prevalence and factors influencing selfmedication based on protection motivation theory (PMT). ........
View PDF View FulltextRapid Diagnosis of Acute Respiratory Infections by Multiplex Endpoint PCR Technology
The multiplex endpoint PCR technology offersa number of potential advantages, results are available in a matter of hours rather than days, the extreme sensibility facilitates de- tection of even minutes the amounts of pathogen DNA in clinical samples and the test is not significantly affected by prior adminis-tration of antibiotics........
View PDF View FulltextMayer- Rokitansky- Kuster- Hauser Syndrome (MRKH SYNDROME)- An Unusual Case of Primary Amenorrhoea
The onset of mestruation is a significant milestone of sexual maturation in a girl child. Although there are numerous causes of primary amenorrhoea, Mayer-Rokitansky-Küster-Hauser (MRKH) syndrome, also known........
View PDF View FulltextCancer Cells-Their Origin
The formation of cells in the body, like the irmutation, isaprocess associated with a violation of the composition and structure of a substance (cells) formed under the influence of an external field surrounding it.........
View PDF View FulltextDelirium Care Pathway Model Design: STOP DELIRIUM
We present a delirium care pathway model that we have dubbed STOPDELIRIUM. Due to delirium's magnitude and effect in elderly hospitalized patients, were commend hospital smusthave a delirium care pathway for early identification, prevention, and delirium management.........
View PDF View FulltextA Case of a Pair of Siblings with Moyamoya Disease
A pair of siblings with Moyamoya disease (MMD) were admitted to our department and treated with superficial temporal artery-middle cerebral artery (STA-MCA) anastomosis and encephalo-myo- synangiosis (EMS).........
View PDF View FulltextCatha Edulis Forskand Its Adverse Effects On Health: Currentand On going Factuality
The leaves of khat tree have an aromatic odor and an astringent and slightly sweet taste. It has been widely chewed for its stimulant action by the population in these regions for many years.Its young buds and tender leaves contain amphetamine-like psy- cho active substances, which produce euphoria and stimulation. Khat is an evergreen shrub,........
View PDF View FulltextA Case of Delayed-Onset Paraplegia at 7 Days After Thoracic Endovascular Aortic Repair
Paraplegia after thoracic endovascular aortic repair (TEVAR) is a common complication, but it is rare for it to occur at 1 week after TEVAR. We describe a patient with delayed-onset paraplegia that occurred 7 days after TEVAR.........
View PDF View FulltextRelationship Between LDH and Mg in Monitoring of Hematologic and Non-Hematologic Malignant Diseases
of this study was to evaluate the correlation between these rumlevels of lactated ehydrogenase (LDH) andma gnesium (Mg) in patients with diagnosed malignant diseases........
View PDF View FulltextFiberoptic Bronchoscopic Treatment of Gastric Aspiration in a Patient with Chest Stomach Ectopia a Case Report
Patients whore ceivedes ophageal resection and gastro-esophageal rebuild before was likely to occur stomach-ectopia to chest when years later. Patients who occurred gastric aspiration during anesthesia have very high risks proceeding to severe aspiration pneumoniaorMendelson’s.......
View PDF View FulltextFatal Anaphylactic Shock from Wasp Sting Despite Desensitisation - A Case Report
Anaphylaxis from Hymenoptera despite conventional venom immunotherapy is rare. We present a case in a previously healthy male with suspected cutaneous mastocytosis, who developed a fatal anaphylaxis due to cerebral hypoperfusion after wasp sting. The report is a reminder that up to 20% of patients allergic to Hymenoptera venom are not protected by conventional venom immunotherapy........
View PDF View FulltextA Protruded Leision with Hemorrhage of Unexpected Histological Findings
An 83-year-old man complained of repeated hematochezia for 3 months.No other medical history was reported except for the percutaneous needle aspiration of left renal cyst 10 years ago. Colonoscopy revealed.......
View PDF View FulltextNon-Structural 5AResistance-Associated Substitutions and Interleukin28B in HCV Genotype 3b Decompensated Cirrhosis Patients with Sofosbuvir Plus Velpatasvir
Hepatitis C Virus (HCV) Genotype (GT) infection is still regarded as one of the more “difficult-totreat”GTs in the era of IFN-free treatments. The viral factors involved in this unfavorable outcome have yet to be clarified.......
View PDF View FulltextGeneralized Eruptive Keratoacanthomas Involving the Auricles and External Auditory Canal:ACase Report and Literature Review
The aim of this study was to report a case of Generalized Eruptive Keratoacan thomas (GEKA) involving theauricl es and external auditory canal and to review the relevant literature.,.......
View PDF View FulltextA Rare Association of a Ruptured Middle Colic Artery Giant Aneurysm and A Celiac Artery Dissection -ACase Report and Literature Review
The occurrence of rupture is the worst among the circumstances of the discovery of a Superior Mesenteric Artery (SMA) branch aneurysm. Despite it remains a rare event, many cases have been reported in the literature. The occurrence correlation of a pancreatico-duodenal aneurysm with isolated celiac artery injury has been proven. However,.......
View PDF View FulltextShort Course Oral Digoxin Treatment inAcute Decompensated Heart Failure: ACase Control Study
Despite many critical voices regarding its efficacy and safety, digoxin may still have a role in the management of heart failure. The objective of this study was to evaluate the efficacy and safety of a short course digoxin therapy started in theemergency department based on clinical outcome after 30 days post hospital discharge........
View PDF View FulltextAcquired SAMD5-RET Fusion-Mediated Resistance to Gefitinib in Metastatic Non-Small Cell Lung Cancer Harboring EGFR-Activating Mutation: A Case Report
Patients with disease progression on first-generation tyrosinekinase in hibitors (TKIs) usually have a poor prognosis.Theme chanisms of acquired resistance to epidermal growth factor receptor (EGFR) TKIs have beenw idely reported; however, reports of acquired rearrangement-during-transfection (RET) fu- sion are rare........
View PDF View FulltextMandibulofacial Dysostosis Guion-Almeida Type: A Syndrome to Recognize in Prenatal
Mandibulofacial dysostosis with microcephaly, Guion-Almeida type (MFDGA) is a rare multiple congenital anomalies syndrome characterized by malar and mandibular hypoplasia, microcephaly, ear malformations with associated conductive hearing loss, esophageal atresia, cleft palate.......
View PDF View FulltextSubclinical Thyroiditis Related to COVID-19: A Case Report and Literature Review
COVID-19 can cause different clinical manifestation by affecting different organs in the body. Involvement of thyroid gland is very rare in COVID-19 infection than any other systems of the body. We described a 41-year-old.......
View PDF View FulltextOver 5 Years of Complete Antiandrogen Withdrawal Response in a Patient with Prostate Cancer: A Case Report
Progressive prostate cancer is primarily treated with androgen-deprivation therapy. The antiandrogen withdrawal (AAW) response (AAWR) is defined as subjective and/or objective improvement following antiandrogen cessation in patients with elevated prostate-specific.......
View PDF View FulltextBilateral Colonic Inguinal Hernia in a Preterm Infant
We presented a case of preterm infant with bilateral colonic inguinal hernia, which was diagnosed radiologically by the initial plain radiograph and subsequent lower gastrointestinal (LGI) study by contrast enema........
View PDF View FulltextTamoxifen May Have a Negative Effect on Bone Mineral Density in Fanconi Syndrome-Related Osteomalacia
A 61-year-old Japanese woman was admitted to our hospital for further examination of generalized bone pain. At age 46 years, the patient was diagnosed with Fanconi syndrome associated with benign monoclonal gammopathy of undetermined significance. At age 56 years, alkaline phosphatase.......
View PDF View FulltextPelvic Solitary Fibrous Tumor
Solitary fibrous tumor is an extremely rare mesenchymal neoplasia divided into pleural and extrapleural form, the latter being considered uncommon........
View PDF View FulltextPlea for an Air-Microbubbles and Air-Blood Interface Free Hemodialysis
Air microbubbles are common in the haemodialysis venous return line, especially in the very first minutes of HD session and with high blood flows. They might be damaging for the lungs microcirculation and stimulate the inflammation system. The origin of air microbubbles is discussed here and practical solutions are proposed to minimize them........
View PDF View FulltextA Case of Retroperitoneal Ectopic Pregnancy and Literature Review
Ectopic pregnancy is a rare female emergency that can have a serious impact on the patient and even threaten life. Retroperitoneal ectopic pregnancy as more rare ectopic pregnancy, its diagnosis and treatment are much .......
View PDF View FulltextThe Use of Essential Oils - Alpha and Β-Pinene in the Treatment of Covid-19
Prophylaxis is not only about wearing masks and vaccines, because no vaccine can guarantee 100% immunity to infection. The best vaccines, based on statistical data from previous years, guarantee approximately 55% certainty of not being infected with a bacterial, viral or fungal infection. Prophylaxis should include a broadly developed psychological .......
View PDF View FulltextBody Packer Syndrome in Sri Lanka
Body packing represents the concealment of illegal substances in a person's body with the aim of smuggling. Body packers either swallow drug-filled packets or introduce drug-filled packets into their bodies through rectum or vagina. In the world, the three main smuggled drugs are cocaine.......
View PDF View FulltextChest Imaging of COVID-19 Pneumonia
A 52-year-old female presented to the emergency department (ED) with fatigue, shortness of breath and cough eight days after being diagnosed with COVID-19. She appeared ill but not toxic, and uncomfortable but not in extremis. Her chest x-ray revealed patchy opacities in bilateral lung bases.......
View PDF View FulltextThe Lethal Effect of COVID-19 on Pregnancy Associated with Neuroendocrine Neoplasm (NEN)
From December 2019, starting from Whuan, COVID-19 pandemic was threatening the entire world population with a major lethal potential. This new infection, with SARS-CoV-2, induces and maintains in human body a significant disturbance in the homeostasis of immune reactions .......
View PDF View FulltextPersistent Hyperglycemia in Brain Tumor Patients Treated with Dexamethasone Peri-Operatively and Post-Operatively
Corticosteroid are commonly used for the management of vasogenic edema and increased intracranial pressure in patients with brain tumors. The purpose of this study was to investigate postoperative and persistent hyperglycemia in patients with brain tumors treated with corticosteroid........
View PDF View FulltextAdult T Cell Lymphoma/Leukaemia with Renal Infiltration: A Case Report from Sri Lanka
Adult T Cell Leukaemia/Lymphoma (ATLL) is a rare T cell lymphoproliferative disease associated with Human T Cell Lymphotropic Virus-1 (HTLV1) endemic in some parts of the world and therefore has a distinct demographic distribution. There are no cases of ATLL.......
View PDF View FulltextMetastasis to Brain and Lung in Carcinosarcoma of the Parotid Gland - A Case Report and Review of Literatures
Carcinosarcoma of the parotid gland is a rare and aggressive malignant mixed tumor in which carcinomatous and sarcomatous elements coexist and metastasize together. The tumor may occur in patients with previous or coexisting pleomorphic adenoma or may arise de novo of the .......
View PDF View FulltextAcute Chlorine Gas Poisoning and Ecg Changes
Chlorine is a yellow-green gas at room temperature. It is an extremely reactive element and a strong oxidizing agent. It has intermediate water solubility and it can cause acute damage to upper and .......
View PDF View FulltextA New Panel of DNA Methylation Biomarkers for Screening Colorectal Cancer and Precancerous Lesions in a Chinese Population
The identification of tumor-specific DNA methylation patterns in epithelial colorectal cells in feces has emerged as a novel and noninvasive screening method for colorectal cancer (CRC) and precancerous lesions. Our study investigates a new panel of DNA methylation biomarkers with high sensitivity and specificity for the early screening of CRC and advanced adenomas in a Chinese population .......
View PDF View FulltextSymphysis Pubis Septic Arthritis
Septic arthritis of symphysis pubis is a rare disease, also known as osteomyelitis of pubic symphysis. It represents less than one percent of all the cases of osteomyelitis. The symptoms are deceiving and can mimic many conditions. This condition usually involves young athletes and women who .......
View PDF View FulltextMedical Schemes and COVID-19 Related Mortality - South Africa: An Explorative Studyt
The COVID-19 epidemic has adversely affected health systems globally, with some on the verge of collapse, as countries experienced the second wave of the pandemic. Millions of people have died from the pandemic, particularly the elderly .......
View PDF View FulltextFatal Attraction: A Case of Multiple Magnet Ingestion in an Infant
Foreign body ingestion is common amongst young children, and they tend to pass spontaneously in most. Multiple magnet ingestion, though not very common, requires early intervention to avoid serious complications........
View PDF View FulltextCongenital True Leukonychia Totalis Case Report, Beyond The Skint
Congenital true leukonychia is an infrequent disorder characterized by a white coloration of the nail since birth without organ or syndromic abnormalities. We present the case of a 16 years old boy with isolated white nail coloration with psychological impact, no syndromic or organ alterations were found........
View PDF View FulltextSmall Cell Carcinoma with Paraneoplastic Cushing’s Syndrome in A 23 -Year-Old A New Observation and Literature Reviewt
A 23 years old girl, without history, consulted for a neck tumefaction appeared 20 days ago, which spread then to the abdomen and lower limbs with Asthenia, dysphagia, abdominal pain, effort dyspnea. Clinical examination revealed an altered general state, obesity with centripetal fat deposition face, supraclavicular and dorsal and cervical fat pads, facial plethora, rounded face, buffalo-hump, face acne, melanodermia, capillary fragility, face, arms and legs hirsutism........
View PDF View FulltextEndoscopic Extraction of a Foreign Body: From Bench to Bedside
Rectal foreign bodies are a common and challenging finding. Here, we present the case of a man who presented to A&E with a courgette. A comprehensive radiological workup and a pre-liminary simulation of the endoscopic technique led to a successful treatment of the case........
View PDF View FulltextMandibular Localizations of Ewing Sarcomas in Children: A Rare Presentation
Ewing’s Sarcoma (ES) is a solid tumor of bone and soft tissue, affecting mainly adolescent and young adults. It is the second most common primary bone tumor in childhood and the most lethal bone tumor. ES is more common in the axial skeleton, head and neck localization is extremely rare (2 to 4%). The purpose of this article is to discuss the case of a young patient diagnosed with mandibular Ewing’s sarcoma and highlight the importance of early diagnosis........
View PDF View FulltextThe Effect of Working from Home as a Result of Covid-19
The coronavirus pandemic hit the world unexpectedly, and to respond swiftly to it, lockdown and social distancing measures had to be implemented to combat its spread. As a result, this forced changes to the working environment since many could not commute to work and have since been working remotely. Due to so many COVID-19 waves that affected different countries at various times, it proved impossible to return to the office and to work from home became entirely possible, and it also reduced the incidence of workers’ unsettlement.e.......
View PDF View FulltextMetastatic Singnet Ring Carcinoma of Unknown Primary Origin with Bilateral Chylothorax: A Case Report
Signet-ring cell carcinoma (SRCC) is defined as a poor prognosis carcinoma and it is not common. Despite the advancement of the technology, origins of about 3%–5% of metastatic tumors remain unknown. Furthermore, metastatic SRCC of unknown primary origin is very rare........
View PDF View FulltextPost vaccination -Multisystemic Inflammatory Syndrome -Adultst
Multi-system inflammatory syndrome in adults (MIS-A) is gaining recognition among adult physicians. MIS-A is a rare but important syndrome that can be difficult to distinguish from severe COVID-19. MIS- A can occur following vaccination for SARS-CoV-2 is not reported till date........
View PDF View FulltextCell Block Biopsy of Portal Vein Thrombosis for Liver Pre-Transplantation Evaluation
Major vessel invasion in patients with hepatocellular carcinoma (HCC) receiving living donor liver transplantation (LDLT) is one of the major factors for HCC recurrence. Malignant portal vein thrombosis (MPVT) is an absolute contraindication for liver transplantation (LT). However, .......
View PDF View FulltextA Giant Gastric Hyperplastic Polyp in Non-Familial Juvenile Polyposis of the Stomach: A Case Report
Juvenile Polyposis Syndrome (JPS) is a rare genetic disorder characterized by juvenile polyps of the gastrointestinal tract, which may also occur in people with no family history of the disorder. It usually involves the colorectum and more rarely the stomach. Juvenile polyps can vary in size from a few millimeters to over 5cm, and, although they have.......
View PDF View FulltextA “3-Level Block” In AVNRT
A 29-year-old woman underwent electrophysiological study for paroxysmal wide-QRS tachycardia with a left bundle branch block (LBBB) aspect (Image A)........
View PDF View FulltextCyclosporine Attenuates Covid-19: Ensnare or Victory
Coronavirus disease 2019 (Covid-19) is a recent worldwide pandemic caused by a novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). In critical cases it causes acute lung injury (ALI) due to severe acute respiratory distress syndrome (ARDS). It has been proposed that initial immunological activation in SARSCoV-2 infection is necessary.......
View PDF View FulltextA Case Report of Fever in Returned Traveller
We report a rare case of severe falciparum malaria in a healthy 28-year-old gentleman in the UK. Malaria is one of the common fatal diseases in tropical countries where doctors are remarkably familiar with handling different types of malaria. In contrast, in the UK, malaria cases are not commonly seen, and all are imported cases so far. As such, clinicians in the UK may not be confident enough to tackle such kind of cases when they encounter them. In this case report, clinical presentation, how to make diagnosis and management of severe falciparum malaria based on our local hospital protocol are emphasized.......
View PDF View FulltextDermatomyositis Revealing Poorly Differentiated Neuroendocrine Carcinoma of the Gallbladder: A Case Report and Review of the Literature
To contribute to the increased understanding of the clinical features of neuroendocrine carcinoma of the gallbladder revealed by a dermatomyositis........
View PDF View FulltextPrimary Retroperitoneal Extraskeletal Mesenchymal Chondrosarcoma Involving the Colon: A Case Report and Literature Review
Extraskeletal mesenchymal chondrosarcoma (EMCS) is an extremely rare malignant tumor arising from soft tissues. It commonly occurs in the lower limbs, orbital cavity, and the central nervous system. Moreover, it is extremely rare for it to develop from a retroperitoneal location. In fact, there is no case about primary retroperitoneal ESMC involving the colon having been reported before.......
View PDF View FulltextToddler’s Fracture; False Positive Radiologic Considerations
Toddler’s fracture is an undisplaced or minimally displaced fracture, typically seen in toddlers, usually in the tibia. It is known as a difficult diagnosis to establish, considering both the clinical symptoms......
View PDF View FulltextFamiliarity with Big Data? A Comparison Between IT Department’s Staff Vs Students of the Universities
The rapid development of technology in recent decades has led to the production of a huge amount of data. One of the challenges of these analyses is the lack of specialized expertise and knowledge in this area. The purpose of this study was to compare the familiarity of IT staff and students with big data analyzes at various universities and organizations........
View PDF View FulltextPainful Encysted Adiponecrosis on the Buttock: Case Report and Etiopathogenic Discussion
Encysted adiponecrosis is a benign subcutaneous lesion characterized histologically by encapsulated fat necrosis. Our purpose was to present and discuss an atypical case of adiponecrosis revealed by a chronic hard mass of soft tissue becoming painful, asso.......
View PDF View FulltextThrombophylia and COVID-19. A Case Report of Young Man 53 Years Old with Acute Cerebral Ischemia
A 57-year-old male was admitted to our Hospital on March 2020 for SARS-Cov2 related interstitial pneumonia. Chest x-ray showed a bilateral interstitial-alveolar pneumonia and Blood gas analysis (BGA) in room air highlighted a severe respiratory failure (pO2 46 mmHg, pH 7.41). D.......
View PDF View FulltextComplement Enhances the Pathogenesis in Autoinflammation Via Induction of A Pro-Inflammatory Microenvironment
The complement system is a complex part of the innate immune system and consists of more than thirty different proteins present in the plasma and on cell membranes. Complement can be activated via three different pathways and may play a role in triggering the NLRP3 inflammasome [1].......
View PDF View FulltextCaroli Syndrome Complicated with Intrahepatic Cholangiocarcinoma
Congenital hepatic fibrosis (CHF) and Caroli disease are two rare genetic diseases. When both conditions are present simultaneously, is known as Caroli syndrome. The main complications are cholangitis and those related to portal hypertension. An uncommon complication but......
View PDF View FulltextFlavones and Phenolic Acids as Potential Inhibitor of B16F10 Melanoma Cells Growth and Modulator of Melanogenesis
Pigmentation disorders leading to discoloration or hyperpigmentary of underlying tissue occur widely and gain interest. This study is within the framework of strategies under-developing safe compounds to modulate melanognonesis pathway. Phenolic acids and flavones were tested for......
View PDF View FulltextCase Reports: Sinus of Valsalva Injury During Percutaneous Coronary Intervention and Perioperative Management
Sinus of Valsalva injury, either due to congenital defect or major traumatic events, was known to be rare. ......
View PDF View FulltextIron Deposit Central Large Nodule in Alagille Syndrome
Alagille syndrome (ALGS) is a multisystem autosomal dominant disorder attributed to defects in the Notch signaling pathway. The mutation of Jagged 1 (JAG1) gene on chromosome 20 has been identified as the underlying cause of this syndrome. In addition, the mutation of Ryanodine receptor......
View PDF View FulltextCase Report: A Clinical Dilemma of Diagnosing Recurrent Incomplete Kawasaki Disease
Kawasaki disease (KD) is one of the most common etiologies of acquired heart disease among children worldwide with unknown pathogen. Early recognition and establishing the diagnosis help the clinical pediatrics practitioner delivering intravenous immunoglobulin treatment......
View PDF View FulltextNon-Traumatic Postpartum Subdural Hematoma: A Case Report of Probable Complication of Preeclampsia
Preeclampsia is a condition that affects nearly 8% of pregnant women, usually during the second half of pregnancy (from around 20 weeks) or soon after their baby is delivered. A spontaneous subdural hematoma......
View PDF View FulltextMiraculous Treatment of Plague in The Island of Corfu from Saint Spyridon: Contribution to The History of Medicine
One of the most important Saints of the Eastern Orthodox Church is Saint Spyridon, Bishop of Tremithus of Cyprus, patron saint of Corfu.......
View PDF View FulltextGravitation - Flat Power Field
A new principle of origin and the nature of the action of gravity forces are proposed. Forces of universal attraction have plane-symmetrical directions.......
View PDF View FulltextDecisions During Covid-19 Pandemic in A Middle-Income Country: A Case Report of Fast-Growing Breast Cancer in A Pregnant Woman
In this Brazilian breast cancer (BC) case report, we described a pregnant woman diagnosed with BC during the beginning of COVID-19 pandemic. The uniqueness of the case reported is related not only to the......
View PDF View FulltextCelidocranial Dysostosis Followed for 25 Years. Presentation of A Case
Cleidocranial Dysostosis is an autosomal dominant scale dysplasia. We present a case of Cleidocranial Dysostosis of a female patient with deformities in the development of the osteomyoarticular system due to clavicular agenesis......
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